Related Experiment Video

Updated: Sep 24, 2025

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta
10:57

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta

Published on: September 12, 2017

8.6K

Changing cell fate in the wall of pulmonary arteries

Yongneng Zhang1, Evangelos D Michelakis1

  • 1University of Alberta, Edmonton T6G 2B7, Canada.

Science Translational Medicine
|May 4, 2022
PubMed

Abstract:

Targeting cell fate may be the most promising approach to treat, reverse, and cure pulmonary arterial hypertension (Zhang et al.).

More Related Videos

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
08:57

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

Published on: July 27, 2022

1.8K
Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro
08:28

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro

Published on: February 15, 2022

3.9K

Related Experiment Videos

Last Updated: Sep 24, 2025

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta
10:57

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta

Published on: September 12, 2017

8.6K
En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
08:57

En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos

Published on: July 27, 2022

1.8K
Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro
08:28

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro

Published on: February 15, 2022

3.9K

Related Concept Videos

Arteries and Arterioles01:16

Arteries and Arterioles

5.1K
Arteries, the vasculature responsible for transporting blood from the heart, possess robust walls capable of enduring the elevated pressures exerted by the heartbeat. Arteries near the heart are especially thick-walled and enriched with elastic fibers across their three tunics, classifying them as elastic or conducting arteries. These arteries, usually with a diameter exceeding 10 mm, are characterized by their ability to dilate in response to the blood pumped from the heart's ventricles...
5.1K

Articles linked to this work by shared authors, journal, and citation graph.

Discovery of a snail hibernation-inducer offering hibernation-like cardioprotection through metabolic rewiring and autophagy in mice.

Nature communications·2026

Selective translation of ZNF281 as part of the integrated stress response system has therapeutic relevance for cardio-oncology.

Science translational medicine·2026

Critical Contribution of Cardiac Myofibroblasts in Right Ventricular Failure and the Role of UCP2 SNPs in the Predisposition to RV Decompensation in Pulmonary Arterial Hypertension.

Circulation·2026

Tumour initiated purinergic signalling promotes cardiomyocyte RBFOX1 degradation and cardiotoxicity from DNA damaging anticancer agents.

Nature communications·2025

TRIM35 Monoubiquitinates H2B in Cardiac Cells, Implications for Heart Failure.

Circulation research·2024

TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure.

Science translational medicine·2022

Closed-loop auditory stimulation in phase with slow waves during sleep enhances cerebrospinal fluid flow in humans.

Science translational medicine·2026

Machine learning-driven spleen imaging and genomics uncover a splenic connection to coronary artery disease.

Science translational medicine·2026

Intravenous gene therapy improves life span and clinical outcomes in a feline model of Sandhoff disease.

Science translational medicine·2026

Oligoclonal nanobody-based recombinant antivenom protects mice challenged with venom from cobras and king cobras from India.

Science translational medicine·2026

Reprogramming engineered autologous T cells to overcome resistance in patients with Merkel cell carcinoma.

Science translational medicine·2026

Proteomics identify disease-associated variants in patients with rare diseases undiagnosed after genome sequencing.

Science translational medicine·2026

Expert Perspective: Toward Treat-to-Target Management in Adult Idiopathic Inflammatory Myopathies.

Arthritis & rheumatology (Hoboken, N.J.)·2026

DAT@Zr-MOF nanocomposite hydrogel accelerates skin wound healing by remodeling the immune-vascular microenvironment.

Journal of materials chemistry. B·2026

Nanoengineered GATA3+ Macrophages Transplantation Reconstitutes the Muscle Stem Cells Niche for Skeletal Muscle Regeneration.

International journal of nanomedicine·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us