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Ademir Melo Leite Filho1, Astrid Carolina Valdivia-Tapia1, Ritta de Cássia Nascimento Pinto Costa2

  • 1Piracicaba Dental School, UNICAMP, Piracicaba, SP, Brazil.

Brazilian Dental Journal
|May 4, 2022
PubMed
Summary

Children's fluoride toothpastes should have at least 1000 ppm soluble fluoride for cavity prevention. Our study found some products in Brazil and Mexico had lower soluble fluoride levels than recommended, despite regulations.

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Area of Science:

  • Dental Public Health
  • Materials Science
  • Analytical Chemistry

Background:

  • Fluoride toothpaste is crucial for preventing childhood caries.
  • Optimal anti-caries efficacy requires a minimum of 1000 ppm soluble fluoride (TSF).
  • Current regulations in Brazil and Mexico were analyzed regarding fluoride content.

Purpose of the Study:

  • To determine total fluoride (TF) and total soluble fluoride (TSF) concentrations in children's toothpastes from Brazil and Mexico.
  • To compare these concentrations with declared values and regulatory standards.
  • To assess fluoride stability in specific formulations over time.

Main Methods:

  • Twenty-four brands from Brazil and six from Mexico were analyzed.
  • Ion-specific electrode method used to quantify TF and TSF concentrations (ppm F).

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  • Fluoride stability tested for Na2FPO3/CaCO3 formulations after 18 months.

    • Main Results:

    • Found TF concentrations ranged from 476.0 to 1385.3 ppm F, aligning with declared values (500-1450 ppm F).
    • All analyzed toothpastes complied with the 1500 ppm F regulatory limit.
    • Some toothpastes, including NaF/SiO2 (500 ppm F) and Na2FPO3/CaCO3 (1000-1100 ppm TF), exhibited TSF concentrations below the recommended 1000 ppm F threshold, even after aging.

    Conclusions:

    • While most toothpastes met TF requirements, some failed to provide adequate TSF for optimal anti-caries effect.
    • Existing regulations in Brazil and Mexico permit the sale of products not fully aligned with scientific evidence on soluble fluoride efficacy.
    • Recommendations for regulatory review and enhanced quality control are suggested to ensure children's oral health protection.