Related Experiment Video
Updated: Sep 24, 2025
03:42
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
Published on: March 29, 2024
1.7K
Mortality from Heart Failure with Mid-Range Ejection Fraction
Giovanni Possamai Dutra1,2, Bruno Ferraz de Oliveira Gomes1,2, Plínio Resende do Carmo Júnior1,2
1Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ - Brasil.
Arquivos Brasileiros De Cardiologia
|May 4, 2022
Summary
The prognostic importance of heart failure (HF) with mid-range ejection fraction (EF) remains uncertain. This study found no significant difference in mortality between HFmrEF, HFpEF, and HFrEF patients, suggesting EF may not be a key predictor.
Area of Science:
- Cardiology
- Clinical Medicine
- Heart Failure Research
Background:
- The prognostic significance of heart failure (HF) with mid-range ejection fraction (HFmrEF) is not well-established.
- Existing classifications of HF based on ejection fraction (EF) include HF with preserved EF (HFpEF) and HF with reduced EF (HFrEF).
Purpose of the Study:
- To investigate the clinical characteristics, comorbidities, complications, and mortality of patients with HFmrEF.
- To compare these factors with those of patients diagnosed with HFpEF and HFrEF upon admission for decompensated HF.
Main Methods:
- An ambispective cohort study involving 519 patients admitted to a cardiac intensive care unit for decompensated HF.
- Statistical analyses included chi-square, ANOVA, Cox multivariate, Kaplan-Meier survival curves, and machine learning techniques (Elastic Net, survival tree).
Main Results:
- HFmrEF constituted 27% of the cohort, with a higher incidence of previous infarction compared to other groups.
- No statistically significant difference in overall mortality was observed between HFpEF, HFmrEF, and HFrEF groups (53.8%, 52.1%, 57.9% respectively).
- Age, previous HF, readmission history, dementia, and vasopressor use were associated with higher late mortality.
Conclusions:
- Ejection fraction was not identified as a variable associated with mortality in patients with decompensated HF.
- The study suggests that HFmrEF may not have a distinct prognostic profile compared to HFpEF and HFrEF regarding mortality.
Related Concept Videos
01:17Pathophysiology of Heart Failure
1.9K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.9K
01:30Heart Failure IV: Classification and Diagnostic Evaluation
52
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
52
01:27Heart Failure I: Introduction
95
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
95
01:30Heart Failure V: Medical Management
36
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
36
01:29Heart Failure II: Pathophysiology
76
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
76
01:26Heart Failure III: Clinical Manifestations
65
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
65