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Updated: Sep 24, 2025

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
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Cysteine metabolic engineering and selective disulfide reduction produce superior antibody-drug-conjugates

Renée Procopio-Melino1, Frank W Kotch2, Amar S Prashad3,4

  • 1BioProcess R&D, Biotherapeutics Pharmaceutical Sciences, Medicinal Sciences, Pfizer Worldwide R&D, 1 Burtt Road, Andover, MA, 01810, USA.

Scientific Reports
|May 4, 2022
PubMed

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