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JNK1 and JNK3: divergent functions in hippocampal metabolic-cognitive function

Oriol Busquets1,2,3,4,5, Triana Espinosa-Jiménez1,3,4, Miren Ettcheto1,2,3,4

  • 1Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacy and Food Sciences Faculty, University of Barcelona, 08028, Barcelona, Spain.

Molecular Medicine (Cambridge, Mass.)
|May 5, 2022
PubMed
Summary

Chronic high-fat diet (HFD) negatively impacts cognition, but JNK1 loss of function protects against metabolic stress and cognitive decline, unlike JNK3.

Keywords:
CognitionHigh-fat dietJNK1JNK3Metabolism

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