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Platelet-leukocyte interactions in COVID-19: Contributions to hypercoagulability, inflammation, and disease severity

Eugenio D Hottz1, Patrícia T Bozza2

  • 1Laboratory of Immunothrombosis Department of Biochemistry Federal University of Juiz de Fora (UFJF) Juiz de Fora MG Brazil.

Research and Practice in Thrombosis and Haemostasis
|May 5, 2022
PubMed

Insights

Platelet-leukocyte interactions in COVID-19 drive hypercoagulability and inflammation, contributing to severe disease. Understanding these interactions is key for developing new therapies to improve outcomes for patients with coronavirus disease 2019.

Area of Science:

  • Hematology
  • Immunology
  • Infectious Diseases

Background:

  • Severe COVID-19 is linked to coagulopathy and thromboembolic events, increasing disease severity and mortality.
  • Mechanisms underlying COVID-19-associated hypercoagulability and thromboinflammation are of significant research interest.

Purpose of the Study:

  • To review mechanisms of platelet activation and leukocyte interactions in COVID-19.
  • To highlight the role of platelet-leukocyte interactions in COVID-19 thromboinflammation and disease severity.

Main Methods:

  • Review of recent evidence and data presented at the 2021 ISTH Congress.
  • Focus on platelet activation, platelet-monocyte, and platelet-neutrophil interactions in COVID-19.

Main Results:

  • Platelet activation and interactions with monocytes and neutrophils in COVID-19 promote thromboinflammation.
  • These interactions contribute to tissue factor expression and NETosis, linked to thromboembolic complications and poor outcomes.

Conclusions:

  • Platelet-leukocyte interactions significantly contribute to COVID-19 immunoregulation, inflammation, and hypercoagulability.
  • Understanding these interactions offers potential therapeutic strategies for improving COVID-19 disease severity and patient outcomes.

Keywords:
COVID‐19monocytesneutrophilsplateletsthromboinflammation

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