Related Experiment Video

Updated: Sep 24, 2025

Efficient Method for Imaging Murine Lungs that Preserves Spatial Dynamics of Fungal Spores in the Airways
10:06

Efficient Method for Imaging Murine Lungs that Preserves Spatial Dynamics of Fungal Spores in the Airways

Published on: December 13, 2024

503

Aspergillosis: An Unwanted Tenant of Lung Cavity in an Immunocompromised Host

Anuradha Sakhuja1, Dhan B Shrestha1, Anurag Adhikari2

  • 1Department of Internal Medicine, Mount Sinai Hospital, Chicago, USA.

Cureus
|May 5, 2022
PubMed

Insights

Immunocompromised patients with breast carcinoma undergoing chemotherapy developed invasive aspergilloma. This fungal infection co-occurred with multi-drug-resistant bacteria and metastatic lung cancer.

Area of Science:

  • Medical Mycology
  • Oncology
  • Infectious Diseases

Background:

  • Immunocompromised individuals are susceptible to opportunistic infections.
  • Cancer patients undergoing chemotherapy face increased risks.
  • Aspergilloma is a fungal infection typically seen in immunocompromised hosts.

Observation:

  • A female breast carcinoma patient on chemotherapy presented with a lung abscess.
  • The patient had a history of lung abscess caused by Klebsiella.
  • Subsequent evaluation revealed aspergilloma within the lung abscess.

Findings:

  • The aspergilloma was associated with multi-drug-resistant organisms.
  • Metastatic breast carcinoma and lung squamous cell carcinoma were found encapsulating the fungal ball.
  • This case highlights a complex interplay of fungal, bacterial, and neoplastic processes.

Implications:

  • This case underscores the critical need for vigilant monitoring of opportunistic infections in immunocompromised cancer patients.
  • Early diagnosis and management are crucial for improving outcomes in such complex cases.
  • Understanding the co-occurrence of fungal infections, resistant bacteria, and cancer metastasis is vital for treatment strategies.
Keywords:
aspergillomaaspergillusbreast carcinomaimmunocompromisedlungs abscess

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