Related Experiment Video
Updated: Sep 24, 2025
Rapid Isolation of Dorsal Root Ganglion Macrophages
Published on: September 7, 2019
LANCL1 as the Key Immune Marker in Neuropathic Pain
Yu Shi1, XueFei Zhang1, Qian Fang1
1Department of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Objective:
This study is to explore key immune markers and changes of immune microenvironment in neuropathic pain (NeuP).
Method:
The data sets of GSE145199 and GSE145226 in Gene Expression Omnibus (GEO) database was used to analyze, and the key immune markers were verified by GSE70006 and GSE91396, and the infiltration degree of immune cells in different samples were analyzed by CIBERSORT analysis package.
Results:
In this study, we found a key immune marker, namely, LANCL1. Regulatory axis closely related to LANCL1 has also been found, namely, miR-6325/LANCL1 axis. In the immune infiltration analysis, we also found that the LANCL1 is positively correlated with T cells CD4 naïve (r = 0.880, p < 0.05).
Conclusion:
In this study, we found that LANCL1 may be a protective factor for NeuP, and the miR-6325/LANCL1 axis may be involved in the occurrence and development of NeuP. Cascade reactions including mast cells, macrophages, and T cells may be an important reason for the aggravation of nerve damage.
