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Synthesis, crystal structure and bioactivities of α-asaronol
Qun Zheng Zhang1, Zhen Hua Zhong1, Ding Hao1
1College of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an 710065, People's Republic of China.
Abstract:
α-Asaronol [or (E)-3'-hydroxyasarone; systematic name: (E)-3-(2,4,5-trimethoxyphenyl)prop-2-en-1-ol; C12H16O4] was synthesized towards the development of a potential antiepileptic drug. Following purification by recrystallization, single crystals of α-asaronol were obtained by a liquid interface diffusion method at room temperature. The product was characterized by 1H and 13C NMR, and FT-IR spectroscopic analysis. X-ray crystallography revealed the title crystal to belong to the orthorhombic space group P212121. Preliminary bioassays with mouse neuroblastoma N2a cells demonstrated the neuroprotective activities of the synthesized α-asaronol.
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