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Insight into the Enterovirus A71: A review.
Robert Kinobe1, Ageng Wiyatno2, I Made Artika1,2
1Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Bogor, Indonesia.
Reviews in Medical Virology
|May 5, 2022
Summary
Enterovirus A71 causes hand, foot, and mouth disease, posing a global health threat, especially to children. This review details its molecular biology and epidemiology to aid vaccine and therapeutic development.
Area of Science:
- Virology
- Molecular Biology
- Epidemiology
Background:
- Enterovirus A71 (EV71) is a primary cause of hand, foot, and mouth disease (HFMD).
- EV71 poses a significant public health risk, particularly for young children in Asia-Pacific regions.
- No US FDA-approved vaccines or antiviral therapies are currently available for EV71 infections.
Purpose of the Study:
- To provide a comprehensive overview of the molecular biology of EV71.
- To summarize the current epidemiological understanding of EV71.
- To guide the development of effective vaccines, therapeutics, and control strategies against EV71.
Main Methods:
- Review of existing scientific literature on EV71.
- Analysis of viral genetic diversity and geographic distribution data.
- Examination of the structure and function of EV71 proteins.
Main Results:
- EV71 is a non-enveloped virus with a positive-sense RNA genome (~7.4 kb).
- Recent advancements have improved understanding of EV71 protein structure, function, genetic diversity, and distribution.
- Licensed EV71 vaccines exist in China, but widespread clinical approval is lacking.
Conclusions:
- A deeper understanding of EV71 molecular biology and epidemiology is crucial.
- This knowledge is essential for developing novel vaccines and antiviral treatments.
- Enhanced preparedness for future EV71 outbreaks is a key objective.
Keywords:
Enterovirus A71Picornaviridaeantiviral agentbiochemistryfoot and mouth diseasegeneticshandmicrobiologymolecular biologymolecular epidemiologyvaccinevirologyMore Related Videos
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