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Osteonectin/SPARC Expression in Head and Neck Squamous Cell Carcinoma: A Tissue Microarray Study.

James S Lewis1, Wade L Thorstad2, Mohammad Hussaini3

  • 1Department of Pathology, Vanderbilt University, Nashville, TN.

Applied Immunohistochemistry & Molecular Morphology : AIMM
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Summary

Secreted protein acidic and rich in cysteine (SPARC) is common in head and neck squamous cell carcinoma stroma. While not linked to overall survival, SPARC stromal expression improved disease-free survival in patients not receiving chemotherapy.

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Area of Science:

  • Oncology
  • Cancer Biology
  • Biomarker Research

Background:

  • Previous studies suggested a correlation between secreted protein acidic and rich in cysteine (SPARC) expression and aggressive behavior in head and neck squamous cell carcinoma (SCC).
  • The role of SPARC in head and neck SCC progression and patient outcomes requires further investigation.

Purpose of the Study:

  • To investigate the impact of SPARC expression on patient outcomes in a large cohort of head and neck SCC.
  • To evaluate the association between SPARC expression and clinicopathologic features.

Main Methods:

  • A cohort of 191 head and neck SCC patients was analyzed.
  • SPARC immunohistochemistry was performed on tissue microarrays.
  • Quantification of cellular and stromal SPARC expression and correlation with clinicopathologic features and survival outcomes.

Main Results:

  • SPARC expression was observed in the tumor cells (65%) and stroma (98%) of head and neck SCC.
  • Increased SPARC stromal expression correlated with poorer overall survival (OS) and disease-specific survival (DSS) in univariate analyses.
  • SPARC expression did not correlate with OS or DSS in multivariate analyses, but was associated with a longer disease-free interval (DFI).
  • Human papillomavirus-positive status correlated with both stromal and tumor SPARC expression.

Conclusions:

  • SPARC is frequently expressed in the tumoral stroma of head and neck SCCs.
  • Contrary to some prior studies, SPARC expression did not correlate with overall survival in this cohort.
  • Subgroup analysis revealed that stromal SPARC expression is associated with better disease-free survival in patients not treated with chemotherapy.