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Recent Updates on Supramolecular-Based Drug Delivery - Macrocycles and Supramolecular Gels
1Interdisciplinary Research Center for Advanced Materials, King Fahd University of Petroleum & Minerals, Dhahran, 31261, Saudi Arabia.
Chemical Record (New York, N.Y.)
|May 5, 2022
Summary
Supramolecular drug delivery using macrocycles and hydrogels shows promise for improving drug solubility, targeting, and responsiveness. Recent advancements in these areas offer new opportunities for research and development in advanced drug formulations.
Area of Science:
- Supramolecular chemistry
- Materials science
- Pharmaceutical sciences
Background:
- Supramolecular drug delivery systems are gaining traction for their ability to improve drug properties like solubility and targeting.
- Macrocycles and supramolecular hydrogels are key supramolecular assemblies explored for drug delivery applications.
Purpose of the Study:
- To review recent advancements in supramolecular drug delivery, focusing on macrocycles and supramolecular hydrogels.
- To highlight the potential of these systems in enhancing drug efficacy and responsiveness.
Main Methods:
- Literature review of recent research on macrocycle-based drug delivery (cyclodextrins, cucurbiturils, calixarenes, etc.).
- Review of studies on supramolecular hydrogels for drug delivery, including those formed by macrocycles/polymers and low molecular weight gelators.
Main Results:
- Detailed overview of drug delivery applications using various macrocyclic compounds.
- Discussion of supramolecular hydrogels, emphasizing their composition and drug delivery capabilities.
- Identification of key advancements and trends in the field.
Conclusions:
- Supramolecular assemblies, particularly macrocycles and hydrogels, represent a vital area for drug delivery innovation.
- Continued research and development in this field are crucial for advancing pharmaceutical formulations and therapeutic outcomes.
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