New strategy of using double-network hydrogel extravascular stent for preventing venous graft restenosis after

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Updated: Sep 24, 2025

Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg
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Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg

Published on: November 19, 2019

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Longsheng Dai1, Wenyuan Yu1, Yang Yu1

  • 1Department of Cardiac Surgery, Beijing An Zhen Hospital, Capital Medical University, Beijing, China.

Perfusion
|May 5, 2022
PubMed
Abstract

Insights

A novel double-network hydrogel external stent (DNHES) effectively prevents vein graft failure in a rabbit carotid artery bypass grafting model. This promising strategy reduces intimal hyperplasia and improves graft survival by modulating key molecular pathways.

Area of Science:

  • Biomaterials Science
  • Vascular Surgery
  • Regenerative Medicine

Background:

  • Vein graft failure, often caused by intimal hyperplasia (IH), remains a significant challenge in coronary artery bypass grafting (CABG).
  • Current therapeutic strategies to prevent vein graft failure are limited, necessitating novel approaches.

Purpose of the Study:

  • To investigate the efficacy of perivenous application of a double-network hydrogel external stent (DNHES) in preventing vein graft failure.
  • To evaluate the impact of DNHES on intimal hyperplasia and graft patency in a rabbit carotid artery bypass grafting model.

Main Methods:

  • New Zealand white rabbits underwent carotid artery bypass grafting using jugular vein grafts.
  • Grafts were either untreated or externally stented with DNHES.
  • Graft blood flow, histology, and molecular markers of proliferation and inflammation were assessed at 12 weeks.

Main Results:

  • DNHES significantly improved graft blood flow compared to untreated grafts.
  • DNHES attenuated intimal and medial thickening, reducing the proliferation index.
  • DNHES decreased the expression of MAPK and TGF-β while increasing eNOS expression.

Conclusions:

  • Perivenous application of DNHES demonstrates beneficial effects on vein grafts, reducing the inflammatory response.
  • DNHES is a safe and promising strategy for preventing vein graft failure in carotid artery bypass grafting.
  • This hydrogel-based approach holds potential for improving outcomes in CABG patients.
Keywords:
Double-network hydrogel extravascular stentcoronary artery bypass graftingintimal and medial thickeningperivenous supportvein graft failure

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