Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

RNA Editing02:23

RNA Editing

9.2K
RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
9.2K
Experimental RNAi02:15

Experimental RNAi

6.3K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.3K
Rab Cascades01:25

Rab Cascades

2.8K
Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
2.8K
Leaky Scanning02:28

Leaky Scanning

5.3K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases.

Current biology : CB·2001
Same author

Pharmacokinetics of 2-hydroxyflutamide, a major metabolite of flutamide, in normal and CCl4-poisoned rats.

Zhongguo yao li xue bao = Acta pharmacologica Sinica·2000
Same author

Flutamide suppressed prostate hypertrophy in rats and mice.

Zhongguo yao li xue bao = Acta pharmacologica Sinica·2000
Same author

Type XV collagen in human colonic adenocarcinomas has a different distribution than other basement membrane zone proteins.

Human pathology·2000
Same author

Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway.

Cardiovascular research·2000
Same author

Dose-dependence of 4-aminopyridine plasma concentrations and electrophysiological effects in dogs : potential relevance to ionic mechanisms in vivo.

Circulation·2000

Related Experiment Video

Updated: Sep 24, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.4K

[Research progress on the relationship between circular RNAs and cataract].

S Y Ma1, J Ma2, D Li1

  • 1Department of Ophthalmology, Eye & ENT Hospital of Fudan University, NHC Key Laboratory of Myopia (Fudan University), Laboratory of Myopia, Chinese Academy of Medical Science, Shanghai 200031, China.

[Zhonghua Yan Ke Za Zhi] Chinese Journal of Ophthalmology
|May 5, 2022
PubMed
Summary

Circular RNAs (circRNAs) impact cataract development by affecting lens cells. Understanding these molecules offers new targets for preventing and treating blindness.

More Related Videos

Use of Alu Element Containing Minigenes to Analyze Circular RNAs
13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

7.4K
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

1.7K

Related Experiment Videos

Last Updated: Sep 24, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.4K
Use of Alu Element Containing Minigenes to Analyze Circular RNAs
13:10

Use of Alu Element Containing Minigenes to Analyze Circular RNAs

Published on: March 10, 2020

7.4K
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

1.7K

Area of Science:

  • Ophthalmology
  • Molecular Biology
  • Genetics

Background:

  • Cataract is a primary cause of global vision impairment and blindness.
  • The exact mechanisms driving cataract formation remain incompletely understood.
  • Circular RNAs (circRNAs), stable non-coding RNAs, are implicated in various biological processes and diseases.

Purpose of the Study:

  • To review current research on the role of circRNAs in cataract.
  • To explore how circRNAs influence lens epithelial cell function.
  • To identify circRNAs as potential therapeutic targets for cataracts.

Main Methods:

  • Literature review of studies investigating circRNAs in cataractogenesis.
  • Analysis of mechanisms by which circRNAs interact with proteins and microRNAs.
  • Examination of the role of circRNA expression in lens epithelial cell function.

Main Results:

  • Abnormal circRNA expression is linked to cataract development.
  • CircRNAs affect lens epithelial cells via protein interactions and microRNA sponging.
  • circRNAs are emerging as key players in the pathogenesis of cataracts.

Conclusions:

  • circRNAs play a significant role in the occurrence and progression of cataracts.
  • circRNAs present promising targets for novel cataract prevention and treatment strategies.
  • Further research into circRNA functions is crucial for advancing ophthalmology.