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Casein-induced experimental amyloidosis. IX. Alterations in marrow dependent function.

D Yonkosky, V Kumar, E S Cathcart

    Immunology
    |July 1, 1978
    PubMed
    Summary

    Multiple injections of sodium caseinate (CAS) or bovine serum albumin (BSA) in mice revealed that amyloidosis impairs marrow-dependent functions, including allograft rejection and viral resistance. Pre-amyloid mice showed enhanced resistance to viral suppression.

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    Area of Science:

    • Immunology
    • Pathogenesis of Amyloidosis
    • Marrow-Dependent Functions

    Background:

    • Amyloidosis is a complex disease affecting multiple organ systems.
    • Marrow-dependent functions play a crucial role in immune responses.
    • The relationship between amyloidosis and immune function requires further investigation.

    Purpose of the Study:

    • To investigate the impact of amyloidosis on marrow-dependent immune functions in mice.
    • To assess the ability of mice to reject bone marrow allografts and resist viral-induced immune suppression.

    Main Methods:

    • CBA/J mice were administered multiple injections of sodium caseinate (CAS) or bovine serum albumin (BSA).
    • Marrow-dependent functions were evaluated by measuring allograft rejection and resistance to Friend virus (FV)-induced suppression of lymphocyte mitogenesis.

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  • Mice were categorized as amyloid, pre-amyloid, or non-amyloid based on treatment and condition.

    • Main Results:

    • Mice that developed amyloidosis lost the ability to reject allogeneic marrow cells.
    • Non-amyloid BSA-treated mice exhibited enhanced rejection of marrow allografts.
    • Pre-amyloid mice (CAS-injected) and non-amyloid mice (BSA-injected) showed increased resistance to FV-induced suppression.
    • Amyloid mice were as susceptible to FV-induced suppression as control mice.

    Conclusions:

    • Alterations in marrow-dependent functions are linked to the pathogenesis of amyloid disease.
    • Amyloidosis significantly impairs immune functions, particularly allograft rejection.
    • Early stages of amyloidosis (pre-amyloid) may involve altered immune responses, including enhanced viral resistance.