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Related Experiment Video

Updated: Sep 24, 2025

Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue
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Elevated Lactate Dehydrogenase Concentrations in Plasma Compared to Serum.

Crystal Bockoven1,2, Robert C Benirschke1,2, Hong-Kee Lee1,2

  • 1Department of Pathology and Laboratory Medicine, NorthShore University HealthSystem, Evanston, IL, USA.

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|May 5, 2022
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Summary

Plasma lactate dehydrogenase (LDH) levels are unpredictably higher than serum LDH. This study suggests returning to serum for LDH testing due to potential platelet interference in plasma samples.

Keywords:
clinical chemistrylactate dehydrogenaseoncologyplasmaplateletsserum

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Area of Science:

  • Clinical Chemistry
  • Biochemistry
  • Laboratory Medicine

Background:

  • Lactate dehydrogenase (LDH) is an enzyme present in most body tissues.
  • Accurate LDH measurement is crucial for diagnosing various conditions.
  • Plasma and serum are common specimen types for laboratory testing, but may yield different results.

Purpose of the Study:

  • To compare lactate dehydrogenase (LDH) concentrations between plasma and serum specimens.
  • To identify potential pre-analytical factors influencing LDH levels in different specimen types.

Main Methods:

  • 110 paired plasma and serum specimens were analyzed for LDH.
  • Hemolytic indices were assessed for both specimen types.
  • Cell counts, including platelet counts, were performed on a subset of specimens.

Main Results:

  • Plasma LDH levels were, on average, 22% higher than serum LDH levels.
  • No significant differences in hemolytic indices were observed between plasma and serum.
  • Increased platelet counts were noted in plasma specimens compared to serum specimens.

Conclusions:

  • Unpredictable elevations in plasma LDH suggest potential interference.
  • Platelet activation or lysis in plasma during storage may elevate LDH levels.
  • Reverting to serum for LDH testing is recommended to ensure reliable results.