Simultaneous acquirement of pure shift 2D homonuclear correlation spectra

Two dimensional homonuclear correlation spectra like COSY, TOCSY and NOESY are classic two-dimensional spectra for analyzing coupling networks and delivering structural information of molecules. Two main challenges of the homonuclear correlation spectra are resolution and efficiency. Because of the complexity of the molecular structure and the effect of scalar coupling, spectral resolution is still difficult to meet the demand, and a higher resolution is needed to improve the quality of the homonuclear correlation spectrum. On the other hand, although some homonuclear correlation spectra are often used together (such as COSY and TOCSY), they are generally sampled separately, and as the number of sampling points in the indirect dimension increases, experiment time increases dramatically. Here, we propose a scheme that can be used to simultaneously obtain indirect dimension pure shift COSY and TOCSY or indirect dimension pure shift COSY and NOESY to improve the resolution of them, while reducing the sampling time and improving the efficiency.