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Biotribological Testing and Analysis of Articular Cartilage Sliding against Metal for Implants
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Multi-material cellular structured orthopedic implants design: In vitro and bio-tribological performance.

M M Costa1, R Lima2, N Alves3

  • 1Center for MicroElectroMechanical Systems (CMEMS-UMinho), University of Minho, Campus de Azurém, 4800-058, Guimarães, Portugal; LABBELS -Associate Laboratory, Braga/Guimarães, Portugal.

Journal of the Mechanical Behavior of Biomedical Materials
|May 5, 2022
PubMed
Summary
This summary is machine-generated.

Selective Laser Melting (SLM) produced advanced Ti64Al4V and NiTi structures. Adding poly-ether-ether ketone (PEEK) significantly enhanced cell performance for improved implant applications.

Keywords:
Bio-tribological experimentsIn vitroMulti-material structuresNiTi-BasedTi6Al4V-based

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Area of Science:

  • Biomaterials Engineering
  • Additive Manufacturing
  • Tissue Engineering

Background:

  • Developing advanced materials for orthopedic implants is crucial for enhancing patient outcomes.
  • Current implant materials face challenges in biocompatibility and long-term performance.
  • Multi-material strategies offer potential for improved implant functionality.

Purpose of the Study:

  • To fabricate and characterize novel mono-material and multi-material cubic cellular structures using Selective Laser Melting (SLM).
  • To evaluate the in vitro biological performance and bio-tribological properties of these structures.
  • To assess the potential of these structures for improving implant performance.

Main Methods:

  • Selective Laser Melting (SLM) was employed to create Ti64Al4V and NiTi cellular structures.
  • Structures were infiltrated with beta-tricalcium phosphate (βTCP) or poly-ether-ether ketone (PEEK) to form multi-material components.
  • In vitro assays assessed cell viability, adhesion, differentiation, and mineralization.
  • Bio-tribological tests were conducted against bovine plate.

Main Results:

  • SLM mono-material groups showed improved metabolic activity and mineralization compared to controls.
  • The addition of PEEK significantly enhanced all tested cell metrics.
  • Beta-tricalcium phosphate (βTCP) infiltration did not yield significant differences in cell performance.
  • Bio-tribological performance was evaluated to mimic implant insertion.

Conclusions:

  • SLM-fabricated Ti64Al4V and NiTi cellular structures demonstrate promising biocompatibility.
  • Poly-ether-ether ketone (PEEK) infiltration is a viable strategy to enhance the biological performance of these structures.
  • These multi-material constructs show potential for developing next-generation orthopedic implants with improved functionality.