Related Experiment Video
Updated: Sep 24, 2025

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Head and neck radiotherapy-induced carotid toxicity: Pathophysiological concepts and clinical syndromes
Alexandre Leboucher1, Sandrine Sotton2, Isabelle Gambin Flandrin1
1Clinique universitaire de radiothérapie, CHU de Grenoble, 38043 Grenoble Cedex 09, France.
Abstract:
This review aims at offering a concise cross-section of head and neck radiotherapy-induced carotid toxicity for pathological concepts to emerge and become part of clinical routine. Radiation-induced carotid toxicities such as atherosclerosis, arterial stiffness and arterioradionecrosis result from radiation dose limitation. Atherosclerosis is related to lesions in the epithelial wall. Such lesions are early radiotherapy-related toxicities and depend on the radiation dose. Atherosclerosis may lead to carotid stenosis and stroke. Arterial stiffness and arterioradionecrosis are late toxicities of the connective tissue that have a low alpha/beta ratio. They are risk factors of pseudoaneurysm and carotid blowout syndrome or stroke in some cases. Because all these pathophysiological mechanisms interfere, post-radiation vascular diseases remain particularly severe and difficult to understand.
More Related Videos
Related Concept Videos
Arteries of the Head and Neck
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

