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Updated: Sep 24, 2025

Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis
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Risk Factors Associated With Postmastectomy Breast Cancer Lymphedema: A Multicenter Retrospective Analysis.

Annet S Kuruvilla1, Aleksandra Krajewski, Xiaoning Li

  • 1From the Department of Surgery, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY.

Annals of Plastic Surgery
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Summary
This summary is machine-generated.

Postmastectomy lymphedema rates have more than doubled between 2010 and 2016. Identifying risk factors like higher comorbidity scores and obesity is crucial for proactive patient management.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Lymphedema Research

Background:

  • Lymphedema significantly impacts postmastectomy breast cancer patients' quality of life and incurs substantial costs.
  • Predictive factors for developing postmastectomy lymphedema remain largely unknown.
  • Understanding lymphedema development is critical for improving patient outcomes.

Purpose of the Study:

  • To analyze trends in lymphedema development after mastectomy from 2010 to 2016.
  • To identify key risk factors associated with lymphedema-related events within two years post-mastectomy.
  • To inform clinical practice and patient monitoring strategies.

Main Methods:

  • Utilized the New York Statewide Planning and Research Cooperative System database (2010-2016).
  • Included 65,543 female breast cancer patients who underwent mastectomy.
  • Employed multivariable modeling to identify predictors of 2-year lymphedema, considering demographics, comorbidities (Elixhauser score), and complications.

Main Results:

  • Overall, 5.2% of patients experienced a lymphedema event within two years post-mastectomy.
  • Lymphedema rates more than doubled from 4.62% in 2010 to 9.75% in 2016 (P < 0.001).
  • Significant risk factors included higher Elixhauser score, prolonged hospitalization, obesity, younger age, non-Asian race, Medicaid insurance, and hypertension (all P < 0.01).
  • Mastectomy type influenced rates, with full mastectomies and lymph node dissections showing higher incidence.

Conclusions:

  • Postmastectomy lymphedema rates have shown a concerning upward trend, necessitating further investigation and management strategies.
  • Identified specific demographic, comorbidity, and surgical factors that increase lymphedema risk.
  • Recommend perioperative screening to proactively identify and monitor high-risk patients for lymphedema development.