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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Transmission-based Precautions II: Airborne and Protective Environment01:25

Transmission-based Precautions II: Airborne and Protective Environment

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Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
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Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
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Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
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Related Experiment Video

Updated: Sep 24, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

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Persistent SARS-CoV-2 Alpha Variant Infection in Immunosuppressed Patient, France, February 2022.

Slim Fourati, Guillaume Gautier, Myriam Chovelon

    Emerging Infectious Diseases
    |May 6, 2022
    PubMed
    Summary
    This summary is machine-generated.

    Persistent circulation of the SARS-CoV-2 Alpha variant was observed in an immunosuppressed patient. This ongoing viral activity highlights the risk of new variants emerging and causing future infection waves.

    Keywords:
    Alpha variantCOVID-19FranceSARSSARS-CoV-2coronaviruscoronavirus diseasemutationsrespiratory infectionssevere acute respiratory syndrome coronavirus 2viruseszoonoses

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    Area of Science:

    • Virology
    • Immunology
    • Infectious Diseases

    Background:

    • Previous variants of concern (VOCs) for SARS-CoV-2 have demonstrated significant global impact.
    • Immunocompromised individuals may experience prolonged infections, potentially leading to viral evolution.

    Purpose of the Study:

    • To document the persistent circulation of a SARS-CoV-2 variant in an immunosuppressed patient.
    • To analyze the mutation accumulation patterns of the circulating variant.
    • To assess the implications for future pandemic waves.

    Main Methods:

    • Case study of an immunosuppressed patient in France.
    • Viral sequencing and phylogenetic analysis to track mutations.
    • Epidemiological context of SARS-CoV-2 variant circulation.

    Main Results:

    • Persistent circulation of the SARS-CoV-2 Alpha variant was identified in February 2022.
    • The virus exhibited a novel pattern of accumulated mutations.
    • The case occurred in an immunosuppressed individual.

    Conclusions:

    • Ongoing circulation of established SARS-CoV-2 variants in vulnerable populations can foster the emergence of new, potentially more transmissible strains.
    • This underscores the need for continued genomic surveillance and management strategies for immunocompromised patients.
    • Previous VOCs may re-emerge and drive future infection waves.