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A cellulose/β-cyclodextrin nanofiber patch as a wearable epidermal glucose sensor.

Kyu Oh Kim1, Geon Jin Kim1, Ji Hye Kim2

  • 1Department of Fiber-System Engineering, Dankook University. 152 Jookjeon-ro, Suji-gu Yongin-si Gyeonggi-do 16890 Republic of Korea kokim@dankook.ac.kr +82-10-3023-0095.

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This study presents a novel cellulose/β-cyclodextrin (β-CD) patch for noninvasive glucose monitoring. The developed sensor shows high accuracy and stability for continuous glucose monitoring, aiding diabetes diagnosis.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Analytical Chemistry

Background:

  • Continuous glucose monitoring (CGM) is crucial for diabetes management.
  • Noninvasive methods are highly desirable to improve patient compliance and reduce complications.
  • Existing CGM technologies often face challenges with accuracy, stability, and invasiveness.

Purpose of the Study:

  • To develop a cellulose/β-cyclodextrin (β-CD) electrospun immobilized glucose oxidase (GOx) enzyme patch.
  • To utilize reverse iontophoresis for noninvasive monitoring of interstitial fluid (ISF) glucose levels.
  • To evaluate the sensor's performance in vitro for potential application in diabetes diagnosis.

Main Methods:

  • Fabrication of a cellulose/β-CD electrospun patch immobilized with glucose oxidase (GOx).
  • Integration of the sensor with a flexible substrate for epidermal application.
  • Utilized reverse iontophoresis for noninvasive extraction of interstitial fluid (ISF).
  • Performed in vitro analysis to assess sensor performance and interference.

Main Results:

  • The developed sensor demonstrated a high diffusion coefficient (9.0 × 10-5 cm2 s-1).
  • Achieved excellent linearity (R 2 = 0.998) with a low detection limit (9.35 × 10-5 M).
  • The sensor exhibited high sensitivity (5.08 μA mM-1) within the linear range (0-1 mM) and was unaffected by common interfering substances at physiological levels.

Conclusions:

  • The cellulose/β-CD electrospun patch with immobilized GOx is a promising candidate for noninvasive glucose monitoring.
  • The sensor's robustness against interfering substances suggests reliable performance in complex biological environments.
  • This epidermal sensing strategy holds significant potential for the continuous glucose monitoring and diagnosis of diabetes.