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A novel multi-reaction microdroplet platform for rapid radiochemistry optimization
Alejandra Rios1,2, Jia Wang1,3, Philip H Chao1,3
1Crump Institute of Molecular Imaging, University of California Los Angeles (UCLA) Los Angeles CA USA mvandam@mednet.ucla.edu.
RSC Advances
|May 6, 2022
Summary
This study introduces a microliter droplet chip for positron emission tomography (PET) tracer development. This chip enables simultaneous reactions, accelerating radiosynthesis optimization and overcoming experimental limitations.
Area of Science:
- Radiochemistry
- Chemical Engineering
- Nuclear Medicine
Background:
- Developing novel tracers for Positron Emission Tomography (PET) requires extensive synthesis optimization.
- Current radiosynthesis optimization is limited by the number of experiments feasible per day.
Purpose of the Study:
- To present a novel microliter droplet chip for accelerating radiosynthesis optimization.
- To overcome practical limitations in daily experimental throughput for PET tracer development.
Main Methods:
- Development of a microliter droplet chip with multiple reaction sites (4 or 16).
- Simultaneous execution of chemical reactions under identical or varied conditions on the chip.
- Application of the chip to radiosynthesis optimization for novel PET tracers.
Main Results:
- The microliter droplet chip allows for parallel experimentation, significantly increasing efficiency.
- Simultaneous reactions under diverse conditions facilitate rapid optimization of synthesis parameters.
- Demonstrated acceleration of the radiosynthesis optimization process.
Conclusions:
- The microliter droplet chip is an effective tool for accelerating radiosynthesis optimization in PET tracer development.
- This technology addresses key limitations in experimental throughput, enabling faster discovery of new PET tracers.
