Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The anal transitional zone.

C Fenger

    Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Supplement
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    The anal transitional zone (ATZ) in the human anal canal, a region with varied terminology, was studied using advanced macroscopic and microscopic techniques. This research clarifies the ATZ

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Surgical Treatment of Acute, Circumscribed, Pulmonary Gangrene; Second Successful Operation.

    The Chicago medical journal and examiner·2023
    Same author

    Variability in plasma concentrations of methylprednisolone 6 days after intrasynovial injection of methylprednisolone acetate in racing horses: A field study.

    Equine veterinary journal·2018
    Same author

    Karyotypic aberrations in an anal-canal malignant-melanoma and its local metastasis.

    International journal of oncology·2011
    Same author

    Microglia and macrophages express tumor necrosis factor receptor p75 following middle cerebral artery occlusion in mice.

    Neuroscience·2006
    Same author

    Eosinophilia in the upper gastrointestinal tract is not a characteristic feature in cow's milk sensitive gastro-oesophageal reflux disease. Measurement by two methodologies.

    Journal of clinical pathology·2006
    Same author

    Randomized study of biennial screening with a faecal occult blood test: results after nine screening rounds.

    Scandinavian journal of gastroenterology·2004
    Same journal

    Trends in cancer incidence in the Nordic countries. A collaborative study of the five Nordic Cancer Registries.

    Acta pathologica, microbiologica, et immunologica Scandinavica. Supplement·1986
    Same journal

    Aleutian disease of mink. Virology and immunology.

    Acta pathologica, microbiologica, et immunologica Scandinavica. Supplement·1985
    Same journal

    Immunomodulatory effects of interferons on human mononuclear cells with special reference to the expression of cell surface antigens.

    Acta pathologica, microbiologica, et immunologica Scandinavica. Supplement·1985
    Same journal

    Location of the binding site in subcomponent C1q for plasma fibronectin.

    Acta pathologica, microbiologica, et immunologica Scandinavica. Supplement·1984
    Same journal

    Cancer epidemiology. Some methodological reflections.

    Acta pathologica, microbiologica, et immunologica Scandinavica. Supplement·1984
    Same journal

    Complement in the serum and venom of Brazilian snakes (Crotalidae).

    Acta pathologica, microbiologica, et immunologica Scandinavica. Supplement·1984
    See all related articles

    Area of Science:

    • Human anatomy and histology
    • Gastrointestinal research
    • Surgical pathology

    Background:

    • Historical descriptions of the human anal canal date back to the 17th century.
    • Existing terminology for the anal canal's three epithelial zones is inconsistent, with numerous names proposed.
    • The precise definition and extent of the anal transitional zone (ATZ) require clarification.

    Observation:

    • The study defines the ATZ as the zone between colorectal mucosa and squamous epithelium, and the dentate line (DL) as the anal valves and sinuses.
    • Macroscopic visualization of the ATZ was achieved using Alcian dyes and stereomicroscopy on surgical specimens.
    • Systematic light microscopy confirmed the macroscopic findings.

    Findings:

    • The ATZ typically extends from the DL upward by approximately 1 cm.

    Related Experiment Videos

  • However, the ATZ's extent can vary significantly, ranging from 0.6 cm below to 2.0 cm above the DL, and it may be absent.
  • The ATZ often exhibits a map-like appearance and is characterized by a stratified epithelium (5-9 cell layers), provisionally termed ATZ-epithelium.

    • Implications:

    • Standardizing terminology for the anal canal's zones, particularly the ATZ and DL, is crucial for clear scientific communication.
    • Accurate delineation of the ATZ's variable extent is important for understanding anal canal physiology and pathology.
    • Further research into the ATZ-epithelium's characteristics may reveal its functional significance.