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Novel dermacozine-1-carboxamides as promising anticancer agents with tubulin polymerization inhibitory activity
Venkata Rao Ghanta1,2, Nagaraju Madala1,2, Aparna Pasula2
1GVK Biosciences Private Limited, Medicinal Chemistry Division 28 A, IDA Nacharam Hyderabad Telangana India balamuraliraman73@gmail.com.
Abstract:
In the present study, novel dermacozine-1-carboxamides (8a-8n) were synthesized and screened for their in vitro cytotoxic activity against three different cancer cell lines: MCF-7 (breast cancer), A-549 (lung cancer) and DU145 (prostate cancer). All the compounds showed more efficiency against the DU145 cell line than against the MCF-7 and A-549 cell lines. Furthermore, 8a (CTC50: 7.02 μM) and 8l (CTC50: 6.32 μM) have been found to be more effective against the DU145 cells as they arrest the cell cycle at the G2/M phase by interfering with tubulin polymerization; these results indicate that these compounds act as potential anti-cancer agents by inhibiting tubulin polymerization.
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