A sodium alginate-based sustained-release IPN hydrogel and its applications
Zuhao Zou1, Bijun Zhang1, Xiaoqin Nie1
1Faculty of Chemistry and Environment Science, Guangdong Ocean University Zhanjiang 524088 China vickygirl7442@163.com.
RSC Advances
|May 6, 2022
Summary
Sodium alginate-based interpenetrating polymer network (IPN) hydrogels offer a stable, porous structure ideal for sustained and controlled drug release. Their biocompatibility ensures maximum drug delivery without compromising therapeutic effects, showing great promise in pharmaceuticals.
Area of Science:
- Polymer Science
- Materials Science
- Pharmaceutical Sciences
Background:
- Interpenetrating polymer network (IPN) hydrogels possess a unique 3D network structure with free volume, enabling sustained and controlled drug release.
- Sodium alginate, a natural polymer, forms stable, porous IPN hydrogels with excellent biocompatibility.
- These properties make alginate-based IPN hydrogels highly suitable for drug delivery applications, maximizing drug efficacy.
Purpose of the Study:
- To provide a comprehensive overview of the formation of alginate-based IPN hydrogels.
- To summarize the various types of alginate-based IPN hydrogels developed.
- To discuss the diverse pharmaceutical applications of these advanced hydrogel systems.
Main Methods:
- Review of literature on the synthesis and characterization of alginate-based IPN hydrogels.
- Analysis of structural properties contributing to controlled release mechanisms.
- Examination of published studies on the efficacy and biocompatibility of these hydrogels in drug delivery.
Main Results:
- Alginate-based IPN hydrogels exhibit tunable porous structures and excellent drug encapsulation capabilities.
- The biocompatibility of sodium alginate ensures minimal impact on drug pharmacology.
- These hydrogels demonstrate significant potential for sustained and controlled release of various therapeutic agents.
Conclusions:
- Alginate-based IPN hydrogels represent a promising platform for advanced drug delivery systems.
- Their formation, types, and applications are crucial for developing effective pharmaceutical formulations.
- Further research in this area can lead to innovative treatments with enhanced patient outcomes.
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