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Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
Published on: November 26, 2017
Structural characterization of ginseng oligopeptides and anti-aging potency evaluation in Caenorhabditis elegans
Qiang Luo1, Jie Liu1, Huailing Wang1
1State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy & Immunology, Shenzhen University School of Medicine Shenzhen 518071 China liuzhigangszu@163.com +86 755-86671911.
Abstract:
The functions of ginseng polysaccharide have been widely explored, yet, the antiaging activity of ginseng oligopeptides (GOPs) has not been well explored. In the current study, seven novel GOPs were isolated, and their antiaging activity was explored in a Caenorhabditis elegans (C. elegans) model. Of interest, all the GOPs showed lifespan extending effects in C. elegans models. Out of the GOPs treatments, 0.75 mM GOP-1 (EHGEYE) prolonged the N2 nematodes lifespan by 42.5%. Additionally, GOP-1 had a strong free radical-scavenging activity, and up-regulated the survival of the N2 C. elegans under oxidative and thermal stresses. Further study revealed that GOP-1 up-regulated the transcription factor daf-16 and jnk-1 expressions, thus we inferred that GOP-1 promotes the lifespan and stress resistances through a JNK-1-DAF-16 pathway. The current study revealed that the ginseng oligopeptides are potential antiaging agents.
