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Related Experiment Video

Updated: Sep 24, 2025

In Vivo Calcium Imaging of Neuronal Ensembles in Networks of Primary Sensory Neurons in Intact Dorsal Root Ganglia

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Additional data for the mouse TRPV6 expression atlas.

Philipp Wartenberg¹, Femke Lux¹, Kai Busch¹

¹Department of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany.

|May 6, 2022

Summary

This summary is machine-generated.

This study maps transient receptor potential vanilloid 6 (TRPV6) expression in mice using a reporter system. The resulting TRPV6 expression atlas reveals cellular-level distribution across various tissues, aiding functional studies.

Keywords:

Calcium Expression Genetic labeling TRP channels

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Last Updated: Sep 24, 2025

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Transpupillary Two-Photon In Vivo Imaging of the Mouse Retina

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Published on: February 13, 2021

Area of Science:

Physiology
Molecular Biology
Genetics

Background:

Transient receptor potential vanilloid 6 (TRPV6) is a calcium-permeable ion channel implicated in various physiological processes.
Understanding TRPV6 expression patterns is crucial for elucidating its diverse roles in different tissues.

Purpose of the Study:

To generate a comprehensive cellular-resolution expression atlas of TRPV6 in adult and juvenile mice.
To provide a valuable resource for researchers investigating the functional significance of TRPV6.

Main Methods:

Utilized TRPV6-IRES-Cre knock-in mice crossed with the enhanced ROSA26-τGFP reporter line.
Collected and imaged organ cryosections from experimental and control animals (both sexes, different ages).
Stained tissue sections for GFP to visualize TRPV6-expressing cells.

Main Results:

Successfully labeled TRPV6-expressing cells with τGFP in TRPV6-IC/eR26-τGFP mice.
Documented reporter gene expression across a wide array of mouse tissues.
Confirmed the absence of τGFP signal in Cre-negative control tissues.

Conclusions:

The generated data constitute the first TRPV6 expression atlas for the mouse at a cellular level.
This atlas provides extensive information to facilitate research into the functional roles of TRPV6 channels in various biological contexts.