A new strategy for synthesizing silver doped mesoporous bioactive glass fibers and their bioactivity, antibacterial
Xiang Qin1, Rong Cao1, Jingjing Zheng1
1College of Chemistry and Chemical Engineering, Yangzhou University Yangzhou 225002 China yaohang@yzu.edu.cn.
Abstract:
A new strategy for preparing mesoporous metal-doped bioactive glass fibers (MBGFs) was designed, which included electrospinning and sulfonating mesoporous PS fibers, precipitating metal ions and bioactive glass sol-gel precursor into the mesoporous polystyrene (PS) fibers and calcinations. Silver-doped mesoporous BGFs (Ag-MBGFs) with a uniform diameter of 1-2 μm and a specific surface area of 40.22 m2 g-1 were prepared as an example and characterized by SEM, XRD, TG, ICP and FTIR. These Ag-MBGFs showed excellent bioactivity, antibacterial properties and drug loading and release performance due to their special mesoporous and fibrous structure. The concentration of Staphylococcus aureus decreased from 1 × 108 colony-forming units per mL (CFU mL-1) to 2.5 × 106 CFU mL-1 in 2 h and then to 2 × 102 CFU mL-1 in 12 h when the concentration of the Ag-MBGFs reached 16 mg mL-1. BGFs of different compositions and functions could be prepared by the same strategy in a mesoporous PS fiber template, which could enrich materials for constructing orthopedic implants.
