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Updated: Sep 24, 2025

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Regio- and stereoselective intermolecular carbolithiation reactions
G Marsico1, P Scafato1, S Belviso1
1Dipartimento di Scienze, Università della Basilicata Via dell'Ateneo Lucano 10 85100 Potenza Italy stefano.superchi@unibas.it +39-971-205503 +39-971-206098.
Abstract:
The inter-molecular carbolithiation of unfunctionalized and functionalized alkenes, followed by electrophile trapping, provides a versatile and useful tool for the construction of complex molecular systems, allowing the simultaneous creation of up to two novel carbon-carbon or carbon-heteroatom bonds. In this review a full overview on inter-molecular carbolithiation processes is reported, with a main focus on the chemo-, regio- and stereo-control of the reaction and on the strategies for asymmetric processes.
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