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Published on: July 20, 2022
Mechanical Circulatory Support for Right Ventricular Failure
Ersilia M DeFilippis1, Veli K Topkara1, Ajay J Kirtane1
1Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons New York, NY, US.
Right ventricular (RV) failure carries high mortality. This review covers mechanical circulatory support devices for RV failure, detailing indications, selection, strategies, and outcomes.
Area of Science:
- Cardiology
- Cardiovascular Surgery
- Critical Care Medicine
Background:
- Right ventricular (RV) failure is a critical condition with high morbidity and mortality rates, often occurring post-cardiac surgery or due to specific conditions like myocardial infarction or pulmonary embolism.
- Medical management for RV failure includes fluid optimization and inotropic/vasopressor support, but some patients require advanced interventions.
- Persistent RV failure necessitates consideration of mechanical circulatory support (MCS) to improve outcomes.
Purpose of the Study:
- To review the current landscape of mechanical circulatory support devices for isolated right ventricular failure.
- To discuss the indications, patient selection criteria, and strategic implementation of various MCS devices.
- To evaluate the outcomes associated with different MCS strategies for RV failure.
Main Methods:
- This review synthesizes current literature on mechanical circulatory support for right ventricular failure.
- It examines percutaneous and surgical MCS options, including micro-axial flow pumps, extracorporeal centrifugal flow RV assist devices, surgically implanted RV assist devices, and veno-arterial extracorporeal membrane oxygenation.
- The review focuses on clinical applications, patient selection, procedural strategies, and patient outcomes.
Main Results:
- Right ventricular failure is associated with in-hospital mortality rates as high as 70-75%.
- Mechanical circulatory support is increasingly utilized for persistent RV failure, offering therapeutic options beyond medical management.
- Various percutaneous and surgical devices are available for isolated RV support, each with specific indications and potential benefits.
Conclusions:
- Mechanical circulatory support offers a vital therapeutic avenue for patients suffering from right ventricular failure.
- Appropriate patient selection, strategic device deployment, and careful management are crucial for optimizing outcomes in RV failure treated with MCS.
- Further research and technological advancements are expected to refine the use of MCS in managing RV failure.
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