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Updated: Sep 24, 2025
Electrochemical Preparation of Poly3,4-Ethylenedioxythiophene Layers on Gold Microelectrodes for Uric Acid-Sensing Applications
Published on: July 28, 2021
Detection of xanthine in food samples with an electrochemical biosensor based on PEDOT:PSS and functionalized gold
M Z H Khan1, M S Ahommed2, M Daizy1
1Dept. of Chemical Engineering, Jashore University of Science and Technology Jashore 7408 Bangladesh zaved.khan@just.edu.bd.
Abstract:
An innovative biosensor assembly relying on glassy carbon electrodes modified with nanocomposites consisting of poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) as a host matrix with functionalized gold nanoparticles (GCE/PEDOT:PSS-AuNPs) is presented for the selective and sensitive detection of xanthine (XA). The developed sensor was successfully applied for the quantification of XA in the presence of significant interferents like hypoxanthine (HXA) and uric acid (UA). Different spectroscopy and electron microscopy analyses were done to characterize the as-prepared nanocomposite. Calibration responses for the quantification of XA was linear from 5.0 × 10-8 to 1.0 × 10-5 M (R 2 = 0.994), with a detection limit as low as 3.0 × 10-8 (S/N = 3). Finally, the proposed sensor was applied for the analyses of XA content in commercial fish and meat samples and satisfactory recovery percentage was obtained.
