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The Function and Regulation of SAPCD2 in Physiological and Oncogenic Processes
1Department of Chemistry and Biochemistry, Texas State University, 601 University Drive, San Marcos, TX, 78666, USA.
Journal of Cancer
|May 6, 2022
Summary
Suppressor APC Domain Containing 2 (SAPCD2) is a gene involved in cell cycle and embryonic development. Aberrant SAPCD2 expression is linked to cancer, making it a potential diagnostic and therapeutic target.
Area of Science:
- Molecular Biology
- Developmental Biology
- Oncology
Background:
- Suppressor APC Domain Containing 2 (SAPCD2) initially identified for cell cycle regulation.
- Emerging evidence links SAPCD2 to embryonic development, cell fate, and planar cell polarity.
- SAPCD2 expression is high in embryogenesis, low in healthy adults, but re-emerges in disease states.
Purpose of the Study:
- To review the current understanding of SAPCD2's normal cellular functions.
- To consolidate knowledge on SAPCD2's role in disease development, particularly tumorigenesis.
- To explore regulatory mechanisms of SAPCD2 expression, including microRNA involvement.
Main Methods:
- Review of published literature on SAPCD2.
- Analysis of in vitro, in vivo, and clinical data regarding SAPCD2's role in cancer.
- Investigation of SAPCD2's oncogenic mechanisms and diagnostic/therapeutic potential.
Main Results:
- SAPCD2 functions extend beyond cell cycle control to embryonic development.
- Aberrant SAPCD2 expression is associated with various cancers, indicating oncogenic potential.
- SAPCD2 shows promise as a diagnostic marker and therapeutic target for cancer.
Conclusions:
- SAPCD2 plays critical roles in both normal development and pathological conditions like cancer.
- Further research is needed to fully elucidate SAPCD2's oncogenic mechanisms and therapeutic applications.
- SAPCD2's involvement in inflammation warrants additional investigation.
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