Long Non-Coding RNAs in the Pathogenesis of Diabetic Kidney Disease

Area of Science:

• Molecular Biology
• Nephrology
• Genetics

Background:

• Diabetic kidney disease (DKD) is a major complication of diabetes mellitus with high global morbidity and mortality.
• Existing therapeutic options for DKD are limited, and its precise pathogenesis remains elusive.
• Oxidative stress, inflammation, and hemodynamic changes are implicated in DKD development.

Purpose of the Study:

• To review the abnormal expression and function of long non-coding RNAs (lncRNAs) in diabetic kidney disease (DKD).
• To summarize the critical roles of lncRNAs in the pathogenesis of DKD.
• To elaborate on the potential therapeutic significance of lncRNAs for DKD treatment.

Main Methods:

• Literature review focusing on lncRNAs in diabetes mellitus and its complications.
• Analysis of lncRNA expression and function in key kidney resident cells (mesangial, endothelial, podocyte, tubular epithelial cells).
• Synthesis of current knowledge on lncRNA involvement in DKD pathogenesis.

Main Results:

• lncRNAs, extensively studied in cancer, are increasingly recognized for their roles in diabetes complications, including DKD.
• Abnormal lncRNA expression and function are observed in major kidney cells, contributing to DKD.
• lncRNAs play critical roles in the initiation and progression of DKD.

Conclusions:

• lncRNAs represent a promising area for advancing the understanding of DKD pathogenesis.
• Targeting lncRNAs may offer novel therapeutic strategies for diabetic kidney disease.
• Further research into lncRNAs can improve future clinical treatment for DKD.