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Updated: Sep 24, 2025

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
A mild and efficient method for the synthesis of pyrroles using MIL-53(Al) as a catalyst under solvent-free
Hai Truong Nguyen1, Linh Ho Thuy Nguyen1,2, Tan Le Hoang Doan1,2
1Faculty of Chemistry, University of Science, Vietnam National University - Ho Chi Minh City 721337 Vietnam thphuong@hcmus.edu.vn.
Abstract:
A highly efficient method for the synthesis of pyrroles using MIL-53(Al) as a catalyst has been developed under solvent-free sonication. This reaction has a broad substrate scope and high yields were obtained within a short reaction time. Remarkably, no additional additives and volatile organic solvent are required for this method and the MIL-53(Al) could be recovered and reused several times without significant drop-off in catalytic activity.
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