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Related Experiment Video

Updated: Sep 24, 2025

Wideband Optical Detector of Ultrasound for Medical Imaging Applications

Wideband Optical Detector of Ultrasound for Medical Imaging Applications

Published on: May 11, 2014

Open-source force analyzer with broad sensing range based on an optical pickup unit.

Tien-Jen Chang¹, Line Hagner Nielsen¹, Anja Boisen¹

¹The Danish National Research Foundation and Villum Foundation's Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Department of Health Technology, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark.

|May 6, 2022

Summary

This summary is machine-generated.

Researchers developed an open-source micro-Newton force analyzer using a DVD player optical pickup. This tool accurately measures the mucoadhesive forces of microdevices, crucial for developing advanced oral drug delivery systems.

Keywords:

3D printing Cantilever Force transducer Microdevices Mucoadhesion Optical pick-up unit

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Last Updated: Sep 24, 2025

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Area of Science:

Pharmaceutical Sciences
Biomedical Engineering
Instrumentation

Background:

Miniaturization of oral drug delivery devices necessitates micro-Newton scale force measurements.
Conventional methods lack the sensitivity for precise micro-Newton force analysis.

Purpose of the Study:

To develop an open-source, highly sensitive force analyzer for micro-Newton scale measurements.
To validate the analyzer's performance in mucoadhesion studies.

Main Methods:

Utilized an optical pickup unit from a DVD player to detect cantilever-based force transducers.
Designed adjustable cantilever force transducers using steel shims, magnets, and 3D-printed components.
Validated the analyzer by investigating porcine intestinal tissue mucoadhesion and measuring microdevice forces.

Main Results:

Achieved a wide force-sensing range from 1.1 N down to 0.99 nN.
Demonstrated reliable measurement of mucoadhesive forces in the micro-Newton range (e.g., 93.7 µN for a microdevice).
Preliminary study showed effects of time and humidity on mucoadhesion.

Conclusions:

The developed open-source force analyzer enables accurate micro-Newton scale force measurements.
This tool supports the advancement of miniaturized oral drug delivery devices.
The analyzer has broad potential applications in various force-sensing fields.