Recent applications of ninhydrin in multicomponent reactions.

Area of Science:

• Organic Chemistry
• Biochemistry
• Analytical Chemistry
• Forensic Sciences

Background:

• Ninhydrin (1,2,3-indanetrione hydrate) is a key compound with broad applications.
• It is increasingly recognized as a valuable building block in organic synthesis.
• Multicomponent reactions involving ninhydrin are gaining attention for scaffold construction.

Purpose of the Study:

• To review ninhydrin-based multicomponent reactions.
• To highlight the synthesis of diverse organic molecules.
• To cover the period from 2014 to 2019.

Main Methods:

• Utilizing ninhydrin in multicomponent reactions.
• Employing readily available starting materials.
• Synthesizing complex molecular architectures.

Main Results:

• Ninhydrin facilitates the rapid construction of versatile molecular scaffolds.
• Simple reactions yield complex structures.
• Synthesized compounds show potential as anticancer agents.

Conclusions:

• Ninhydrin-based multicomponent reactions are efficient for generating diverse organic molecules.
• These reactions provide a pathway to novel compounds with potential therapeutic applications.
• The review underscores the significance of ninhydrin in modern synthetic chemistry.