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Controlled trial of trimeprazine tartrate for night waking
Insights
Trimeprazine tartrate effectively reduces night waking in young children. This mild hypnotic offers short-term relief for persistent sleep issues in toddlers, improving overall sleep quality.
Area of Science:
- Pediatric Sleep Medicine
- Clinical Pharmacology
Background:
- Mild hypnotics are frequently prescribed for pediatric sleep disturbances.
- Persistent and severe night waking affects young children's well-being and family life.
Purpose of the Study:
- To evaluate the efficacy of trimeprazine tartrate in treating night waking in 1 to 3 year old children.
- To compare trimeprazine tartrate's effectiveness against a placebo in a controlled trial.
Main Methods:
- A double-blind, placebo-controlled crossover trial was conducted.
- Participants were children aged 1 to 3 years with severe night waking.
- Sleep variables were monitored during treatment periods.
Main Results:
- Children treated with trimeprazine tartrate experienced significantly fewer night wakings.
- Trimeprazine tartrate led to reduced time awake at night and increased total sleep time.
- No significant differences were observed between the first and fourth weeks of drug treatment.
Conclusions:
- Trimeprazine tartrate demonstrates efficacy as a short-term treatment for night waking in young children.
- The study supports the use of trimeprazine tartrate for improving sleep in toddlers.
- Long-term effects and efficacy beyond short-term use require further investigation.
Abstract:
Mild hypnotics are often recommended for young children with sleep problems. This study assesses the efficacy of trimeprazine tartrate in 1 to 3 year old children with persistent and severe night waking in a double blind crossover trial with placebo. Children on treatment with trimeprazine had significantly fewer wakings, less time awake at night, and more night time sleep compared with those on treatment with placebo. There were no differences in these sleep variables when the first and last (fourth) week of treatment with drugs were compared. Follow up observations showed no significant difference in any sleep variables from baseline measures. The results are consistent with the idea that trimeprazine tartrate may be a useful short term treatment for night waking in young children.