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Phosphonopeptides containing free phosphonic groups: recent advances
1Department of Bioorganic Chemistry, Wrocław University of Science and Technology Wybrzeże Wyspiańskiego 27 50-305 Wrocław Poland pawel.kafarski@pwr.edu.pl.
RSC Advances
|May 6, 2022
Summary
Phosphonopeptides, peptide mimetics with phosphonic acid groups, show promise as enzyme inhibitors. This review focuses on those with free phosphonic acid moieties, highlighting their antimicrobial and research applications.
Area of Science:
- Medicinal Chemistry
- Biochemistry
- Organic Chemistry
Background:
- Phosphonopeptides are peptide mimetics where phosphonic acid or related groups replace key peptide components.
- These compounds act as enzyme inhibitors, exhibiting physiological activities with potential medical and agricultural applications.
- Previous reviews covered C-terminal diaryl phosphonates and phosphonic acid peptide bond mimics; this review focuses on free, unsubstituted phosphonic acid moieties.
Purpose of the Study:
- To review phosphonopeptides containing free, unsubstituted phosphonic acid groups.
- To highlight the synthesis and biological properties of these specific phosphonopeptide classes.
- To discuss their potential applications in medicine and agriculture.
Main Methods:
- Literature review focusing on phosphonopeptides with free phosphonic acid.
- Categorization of phosphonopeptides into two main groups based on structure.
- Analysis of reported biological activities and applications.
Main Results:
- Identified two main classes: C-terminal aminophosphonic acid peptides and non-hydrolyzable phosphonoamino acid analogues.
- Many C-terminal aminophosphonic acid peptides, including natural products, exhibit antimicrobial activity.
- Phosphonoamino acid analogues serve as valuable tools for studying phosphorylation effects.
Conclusions:
- Phosphonopeptides with free phosphonic acid moieties represent a significant area of research.
- These compounds demonstrate broad potential, particularly in antimicrobial applications and as biochemical research tools.
- Further investigation into their synthesis and biological activity is warranted for therapeutic and agricultural development.
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