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Cortical spreading depression and meningeal nociception
Simone Carneiro-Nascimento1, Dan Levy1
1Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, United States.
Neurobiology of Pain (Cambridge, Mass.)
|May 6, 2022
Summary
Migraine with aura involves pain originating from the cranial meninges. Cortical spreading depression is a key process driving meningeal nociception, offering potential therapeutic targets for migraine treatment.
Area of Science:
- Neuroscience
- Pain Research
- Neurology
Background:
- Migraine imposes a substantial global health and economic burden.
- Inadequate current treatments necessitate novel therapeutic strategies.
- Understanding migraine pain mechanisms is crucial for developing new therapies.
Purpose of the Study:
- To review the mechanisms of headache genesis in migraine with aura.
- To focus on the role of cortical spreading depression in meningeal nociception.
- To discuss potential therapeutic targets for migraine treatment.
Main Methods:
- Review of recent scientific literature.
- Focus on animal studies investigating migraine mechanisms.
- Analysis of the link between cortical spreading depression and meningeal nociception.
Main Results:
- The sensory innervation of cranial meninges is implicated in migraine pain.
- Cortical spreading depression is a critical factor in meningeal nociception for migraine with aura.
- Recent research provides insights into underlying mechanisms driving meningeal pain.
Conclusions:
- Targeting meningeal nociceptive pathways may offer novel migraine treatments.
- Further research into cortical spreading depression is warranted for migraine therapy development.
- A deeper understanding of migraine mechanisms can lead to improved patient outcomes.
Keywords:
ATP, adenosine triphosphateCCL2, C–C motif chemokine ligand 2COX, cyclooxygenaseCSD, cortical spreading depressionCSF, cerebrospinal fluidCa2+, calcium ionsCortical spreading depressionHMGB1, high mobility group box protein 1IL-1β, interleukin 1 betaIL-6, interleukin 6K(ATP), ATP-sensitive potassium channelsK+, potassium ionsKCl, potassium chlorideMeningeal nociceptionMigraineNK-1, neurokinin-1NMDA, N-methyl-D-aspartateNaCl, sodium chlorideTG, trigeminal ganglionTNC, trigeminal nucleus caudalis
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