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Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

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Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
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Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
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In gas chromatography, different detectors are employed to meet specific analytical needs. These detectors are often categorized based on their detection mechanisms and the types of compounds they are best suited to analyze. Thermal Conductivity Detectors (TCD), Flame Ionization Detectors (FID), and Electron Capture Detectors (ECD) represent common categories, each with unique operating principles and applications. However, beyond these, several other detectors are designed for more specialized...
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Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
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Enabling Real-Time Compensation in Fast Photochemical Oxidations of Proteins for the Determination of Protein Topography Changes
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"Popper" induced methemoglobinemia.

Fares Elgendy1, Gaspar Del Rio-Pertuz2, Dalena Nguyen2

  • 1Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Proceedings (Baylor University. Medical Center)
|May 6, 2022
PubMed
Summary

Recreational amyl nitrite ("poppers") use can cause methemoglobinemia, a dangerous blood disorder where red blood cells cannot effectively carry oxygen. This case highlights the risks associated with inhaling these volatile nitrites.

Area of Science:

  • Hematology
  • Toxicology
  • Pharmacology

Background:

Keywords:
Amyl nitratesmethemoglobinemiapopper

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  • Methemoglobinemia is a condition characterized by elevated levels of methemoglobin in red blood cells, impairing oxygen transport.
  • It can be acquired or congenital, with acquired cases often linked to exposure to nitrates or nitrites.
  • Volatile nitrites, known as "poppers," are inhaled for recreational purposes, primarily for their vasodilatory and aphrodisiac effects.