[Reactions to heterogeneous lyophilized tissue material implanted into the peritoneal cavity of the rat]

Resorption rate of heterogeneous implants (lyophilized tissues of the rabbit liver and cerebriform cancer of the human stomach) has been studied 6, 24 h and 3, 7, 21, 30 days after their simultaneous implantation into the rat peritoneal cavity. The area of separate cellular zones, contents of granulocytes and immune-competent cells in the zone macrophage-fibroblasts, mitotic coefficient and index of 3H-thymidin-labelled fibroblast nuclei have been taken into consideration. Resorption and elimination rate of the protein implants applied, as well as proliferation of the connective tissue elements and maturation of the granulation tissue in the organization focus take place more quickly at implantation of the lyophilized tumoral tissue. Antigenic reaction to the native hepatic proteins and to the stomach cancer occurs in the same way as to alive cells. Its index is appearance of the zone consisting of lymphocytes with plasma cells in the periphery of the implants.