Design, synthesis and properties investigation of N ^α-acylation lysine based derivatives

Amino acid-based compounds have attracted attention as environmentally friendly bio-based materials. Our group has recently developed a novel family of N ^α-acylation lysine based derivatives. We introduced long chain acyl groups at the N ^α position selectively by a new synthetic route that avoided the process of amino protection and deprotection. Sodium N ^α-octanamide lysine (C8), sodium N ^α-capramide lysine (C10) and sodium N ^α-lauramide lysine (C12) can self-assemble into vesicles spontaneously. As a result, not only do they have potential in drug delivery system but also they may be used as bio-based surfactants applied in cosmetics and other industries.