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Expansion of Two-dimension Electrospun Nanofiber Mats into Three-dimension Scaffolds
Published on: January 7, 2019
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New surgical meshes with patterned nanofiber mats
Pengbi Liu1,2, Nanliang Chen1, Jinhua Jiang1
1College of Textiles, Donghua University Shanghai 201620 P. R. China jiangjinhua@dhu.edu.cn.
RSC Advances
|May 6, 2022
Summary
This study improved surgical meshes for hernia repair by optimizing textile structures and adding nanofibers. These enhanced meshes better mimic the abdominal wall, improving cell interactions and potentially reducing complications.
Area of Science:
- Biomedical Engineering
- Materials Science
- Textile Engineering
Background:
- Abdominal wall hernia repair is common, with surgical meshes improving outcomes but causing complications like pain and recurrence due to mechanical mismatch.
- Current meshes have limitations in mimicking the mechanical properties of the human abdominal wall.
Purpose of the Study:
- To design and evaluate novel warp-knitted polypropylene (PP) meshes with improved properties for hernia repair.
- To investigate the effect of patterned nanofiber coatings on mesh performance and cellular response.
Main Methods:
- Developed six warp-knitted polypropylene (PP) meshes with varied textile structures.
- Electrospun poly-caprolactone (PCL) nanofibers onto PP meshes, creating patterned scaffolds.
- Analyzed nanofiber morphology, diameter, and cell adherence, proliferation, and morphology on the scaffolds.
Main Results:
- Mesh textile structures were optimized to better mimic abdominal wall performance.
- Patterned nanofiber mats with diverse morphologies and diameters were formed on the meshes.
- Nanofiber coatings enhanced cell adherence and proliferation, with aligned nanofibers promoting better cell elongation and orientation.
Conclusions:
- Optimized textile structures and nanofiber coatings can significantly improve hernia repair mesh properties.
- Scaffold pattern influences cell morphology, suggesting potential for tailored tissue regeneration.
- This research paves the way for developing advanced biomedical scaffolds for hernia repair.
