Ruthenium-catalyzed, site-selective C-H activation: access to C5-substituted azaflavanone
Manickam Bakthadoss1, Tadiparthi Thirupathi Reddy1, Duddu S Sharada2
1Department of Chemistry, Pondicherry University Puducherry - 605014 India bhakthadoss@yahoo.com.
Abstract:
A site-selective ruthenium-catalyzed keto group assisted C-H bond activation of 2-aryl tetrahydroquinoline (azaflavanone) derivatives has been achieved with a variety of alkenes for the first time. A wide range of substrates was utilized for the synthesis of a wide variety of alkenylated azaflavanones. This simple and efficient protocol provides the C5-substituted azaflavanone derivatives in high yields with a broad range of functional group tolerance. Further, the C5-alkenylated products were converted into substituted 2-aryl quinoline derivatives in good yields.
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