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Related Concept Videos

Pharmacovigilance01:19

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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
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Nonlinear Pharmacokinetics: Overview01:19

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Nonlinear or dose-dependent pharmacokinetics is a phenomenon that occurs when the pharmacokinetic parameters of certain drugs deviate from linear pharmacokinetics at higher doses. These drugs do not follow the expected first-order kinetics, where the rate of drug elimination is directly proportional to the drug concentration. Instead, they exhibit a nonlinear relationship, which can be attributed to several factors.
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Noncompartmental Analysis: Mean Residence Time01:05

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According to statistical moment theory, mean residence time (MRT) is an important measure in pharmacokinetics. MRT can be defined as the expected mean of a probability density function distribution. It provides valuable insights into drug disposition in the body.
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Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
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Real-Time Risk Tool for Pharmacy Interventions.

Hanh L Nguyen1, Kristin S Alvarez1, Boryana Manz2

  • 1Parkland Health and Hospital System, Dallas, TX, USA.

Hospital Pharmacy
|May 6, 2022
PubMed
Summary
This summary is machine-generated.

A risk tool accurately identified high-risk patients, significantly reducing hospital readmissions through targeted medication histories. This approach optimizes resource allocation for better patient outcomes in healthcare settings.

Keywords:
adverse drug reactionsclinical pharmacy servicesmedication safetymedication therapy managementmonitoring drug therapytechnicians

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Area of Science:

  • Health Services Research
  • Clinical Pharmacy
  • Patient Safety

Background:

  • Adverse drug events (ADEs) contribute to increased hospitalizations.
  • Comprehensive admission medication histories (AMHs) can prevent ADEs but are resource-intensive.
  • Electronic Medical Record (EMR) risk prediction models can help target resources.

Purpose of the Study:

  • To evaluate if an AMH scoring tool can decrease 30-day hospital readmissions.
  • To assess the tool's effectiveness in allocating pharmacy resources for AMHs.

Main Methods:

  • A propensity-matched cohort study was conducted in a large academic safety-net hospital.
  • Pharmacy-conducted AMHs were implemented for patients identified as high-risk by an EMR-based scoring tool.
  • Standard of care AMH was provided to the control group.

Main Results:

  • The study included 4027 patients per group, screened from 87,240 hospitalizations.
  • High-risk patients receiving pharmacy-conducted AMHs had significantly lower 30-day readmissions (11% vs. 15%, P=0.004).
  • No significant difference in readmissions was observed for low-risk patients; however, ADE prevention documentation was higher in the intervention group.

Conclusions:

  • An EMR-embedded risk tool effectively identifies patients for targeted AMHs.
  • Significant reductions in readmissions were achieved for high-risk patients.
  • Resource allocation should prioritize high-risk patients to maximize the benefit of AMHs.