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Expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors
Anna Esposito1, Eliana De Gregorio2, Maria De Fenza1
1Department of Chemical Sciences, University of Napoli Federico II Via Cintia 80126 Napoli Italy annalisa.guaragna@unina.it.
RSC Advances
|May 6, 2022
Abstract:
The synthesis of deflazacort (DFZ) and a preliminary evaluation of its microbial activity against the human pathogens Acinetobacter baumannii and Staphylococcus aureus is herein reported. While DFZ is inactive, one of its synthetic precursors showed a strong antibacterial activity against both Gram-negative and -positive bacteria.
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