Enhanced photodegradation of diphenhydramine in aqueous solution containing natural sand particles

Understanding the effects of natural solid particles on the phototransformation of pharmaceuticals in aqueous environments is very important, but studies on this are still limited. In this study, natural sands were selected as a solid particle model due to their wide distribution in surface waters during the rainy season, and the phototransformation of diphenhydramine (DP) in the presence of the sands was investigated. The kinetic studies showed that the natural sands exhibited significant photocatalytic activity for the DP photodegradation, and the activity varied depending on their sources. Scavenging experiments and electron paramagnetic resonance analysis demonstrated that O₂ ^-˙ and ˙OH were produced in the irradiated natural sand systems, and O₂ ^-˙ played a more important role than ˙OH in the photodegradation of DP. The results obtained from H₂O₂ treatment and deoxygenation experiments verified that the generation of radicals was mainly attributed to the low content of natural organic matter (NOM) in the sands. The possible reaction mechanism was that the NOM in the sands was excited and became triplet-state NOM after irradiation, and then induced the generation of free radicals through an electron transfer mechanism, resulting in DP oxidation. This work indicated that natural sand particles were a key factor affecting the phototransformation of drugs, and should be considered in evaluating their fate in natural waters.