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Updated: Sep 24, 2025

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Recent advances in the synthesis of ferrocene derivatives via 3d transition metal-catalyzed C-H functionalization
Zhuo-Zhuo Zhang1, Dan-Ying Huang2, Bing-Feng Shi3
1School of Food and Biological Engineering, Chengdu University, Chengdu, Sichuan, 610106, China. zhangzhuozhuo@cdu.edu.cn.
Abstract:
In recent years, transition-metal-catalyzed C-H functionalization has gradually developed into a powerful tool for the synthesis of ferrocenes in an atom- and step-economic fashion. However, despite significant achievements, the vast majority of these C-H functionalizations required precious 4d or 5d transition metal catalysts. The use of inexpensive and sustainable 3d metals in the C-H functionalization of ferrocenes remains challenging, especially the development of asymmetric versions. Herein, we summarize the remarkable recent progress in the synthesis of ferrocenes by 3d transition metal-catalyzed C-H activation until December 2021.
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