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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
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Extrinsic and Intrinsic Pathways of Hemostasis01:20

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Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
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Venous Thrombosis IV: Nursing Management01:30

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Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
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Disorders of Erythrocytes01:27

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Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
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Updated: Sep 24, 2025

Microfluidics in Assessing Platelet Function
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Acquired bleeding disorders.

Andreas Tiede1, Barbara Zieger2, Ton Lisman3

  • 1Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.

Haemophilia : the Official Journal of the World Federation of Hemophilia
|May 6, 2022
PubMed
Summary
This summary is machine-generated.

Acquired bleeding disorders, including acquired hemophilia A and von Willebrand syndrome, arise from various diseases or spontaneously. This review covers their pathophysiology, diagnosis, and treatments.

Keywords:
Coagulation Protein DisordersHemophilia ALiver diseaseVon Willebrand Disease

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Area of Science:

  • Hematology
  • Internal Medicine
  • Autoimmunology

Background:

  • Acquired bleeding disorders can be associated with hematological, neoplastic, autoimmune, cardiovascular, or liver diseases.
  • These disorders may present as isolated factor deficiencies or complex hemostatic issues.
  • They can also manifest spontaneously without an identifiable underlying condition.

Purpose of the Study:

  • To review acquired bleeding disorders, focusing on acquired hemophilia A, acquired von Willebrand syndrome, and liver function disorders.
  • To provide an overview of the pathophysiology, diagnostic approaches, and current treatment strategies for these conditions.
  • To elucidate the complex hemostatic abnormalities and their clinical implications.

Main Methods:

  • Literature review of acquired bleeding disorders.
  • Analysis of pathophysiology, diagnostic tests, and treatment strategies.
  • Focus on acquired hemophilia A, acquired von Willebrand syndrome, and liver function disorders.

Main Results:

  • Acquired hemophilia A involves autoantibodies against coagulation factor VIII.
  • Acquired von Willebrand syndrome results from shear stress-induced destruction of von Willebrand factor in cardiovascular disease.
  • Liver disease causes complex pro- and anti-hemostatic factor changes with unpredictable clinical outcomes.

Conclusions:

  • Understanding the specific pathophysiology is crucial for diagnosing and managing acquired bleeding disorders.
  • Current diagnostic tools and treatment strategies offer improved patient outcomes.
  • Further research is needed to fully predict and manage the clinical implications of complex hemostatic abnormalities.